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Merck
CN

PZ0306

PF-6808472

≥98% (HPLC)

Synonym(s):

4-{4-[4-(5-Cyclopropyl-1H-pyrazol-3-ylamino)-6-prop-2-ynylcarbamoyl-pyrimidin-2-yl]-piperazin-1-ylmethyl}-benzenesulfonyl fluoride, XO44

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About This Item

Empirical Formula (Hill Notation):
C25H27FN8O3S
CAS Number:
2088112-70-1
Molecular Weight:
538.60
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

F[S](=O)(=O)c1ccc(cc1)CN2CCN(CC2)c3nc(cc(n3)C(=O)NCC#C)Nc4n[nH]c(c4)C5CC5

InChI key

ZBSPMOBILDLOCV-UHFFFAOYSA-N

InChI

1S/C25H27FN8O3S/c1-2-9-27-24(35)21-15-22(29-23-14-20(31-32-23)18-5-6-18)30-25(28-21)34-12-10-33(11-13-34)16-17-3-7-19(8-4-17)38(26,36)37/h1,3-4,7-8,14-15,18H,5-6,9-13,16H2,(H,27,35)(H2,28,29,30,31,32)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

PF-6808472 is a cell permeable covalent probe suitable for click chemistry designated to measure kinase selectivity in intact cells. PF-6808472 contains sulfonyl fluoride group, which react with conserved lysine residue within kinase ATP binding site.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000403635
0000403635
0000253526
0000253526
0000188159

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Qian Zhao et al.
Journal of the American Chemical Society, 139(2), 680-685 (2017-01-05)
Protein kinases comprise a large family of structurally related enzymes. A major goal in kinase-inhibitor development is to selectively engage the desired kinase while avoiding myriad off-target kinases. However, quantifying inhibitor interactions with multiple endogenous kinases in live cells remains

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