PZ0346
PF-06726304 acetate
≥98% (HPLC)
Synonym(s):
5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
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About This Item
Empirical Formula (Hill Notation):
C22H21Cl2N3O3 · C2H4O2
CAS Number:
Molecular Weight:
506.38
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
CC(O)=O.CC(ON=C1C)=C1C2=CC(Cl)=C(CCN(CC3=C(C)C=C(C)NC3=O)C4=O)C4=C2Cl
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
PF-06726304 is a selective inhibitor of Histone-lysine N-methyltransferase EZH2 (enhancer of Zeste homolog 2), which catalyzes trimethylation of histone H3 lysine 27 (H3K27) and is amplified and/or overexpressed in several human cancers including breast, prostate and lymphoma. PF-06726304 is a novel structural class of EZH2 inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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