PZ0348
NI-42
≥98% (HPLC)
Synonym(s):
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C18H15N3O3S
CAS Number:
Molecular Weight:
353.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C18H15N3O3S/c1-12-9-14-10-15(5-8-17(14)21(2)18(12)22)20-25(23,24)16-6-3-13(11-19)4-7-16/h3-10,20H,1-2H3
InChI key
BMVCSXFOQPYKKC-UHFFFAOYSA-N
SMILES string
CC1=CC2=CC(NS(=O)(C3=CC=C(C#N)C=C3)=O)=CC=C2N(C)C1=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
Biochem/physiol Actions
NI-42 is a biased potent small molecule inhibitor of the bromodomain of the BRPF (bromodomain and PHD finger-containing) proteins, which are scaffolding proteins that assemble histone acetyltransferase (HAT) complexes of the MYST transcriptional coactivator family. NI-42 has an IC50 value of of 7.9 nM and is suitable for cellular and in vivo studies.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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