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Merck
CN

PZ0360

PF-4191834

≥98% (HPLC)

Synonym(s):

4-(3-(4-(1-Methyl-1H-pyrazol-5-yl) phenylthio) phenyl)-tetrahydro-2H-pyran-4-carboxamide, PF 4191834, Tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C22H23N3O2S
CAS Number:
1029317-21-2
Molecular Weight:
393.50
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD18382581

Key Documents

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InChI

1S/C22H23N3O2S/c1-25-20(9-12-24-25)16-5-7-18(8-6-16)28-19-4-2-3-17(15-19)22(21(23)26)10-13-27-14-11-22/h2-9,12,15H,10-11,13-14H2,1H3,(H2,23,26)

SMILES string

NC(C1(CCOCC1)C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)=O

InChI key

DVNQWYLVSNPCJZ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

PF-4191834 is known to reduce the indications of arthritis.
PF-4191834 a selective, non-redox, non-iron chelating competitive inhibitor of 5-lipoxygenase effective in inflammation and pain.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000022390
0000022391
0000019306

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Jaime L Masferrer et al.
The Journal of pharmacology and experimental therapeutics, 334(1), 294-301 (2010-04-10)
5-Lipoxygenase (LOX) is an important arachidonic acid-metabolizing enzyme producing leukotrienes and other proinflammatory lipid mediators with potent pathophysiological functions in asthma and other inflammatory diseases. 4-(3-(4-(1-Methyl-1H-pyrazol-5-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide (PF-4191834) is a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. In
Han-Ching Lin et al.
PloS one, 9(9), e107890-e107890 (2014-09-18)
The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis. However, the detailed mechanism of how 5-lipoxygenase regulates the inflammatory response in arthritis synovial tissue

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