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Merck
CN

PZ0407

PF-04957325

≥98% (HPLC)

Synonym(s):

3-[[(2R)-4-(2-Thiazolylmethyl)-2-morpholinyl]methyl]-5-(trifluoromethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine, 3-[[(2R)-4-(thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine

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About This Item

Empirical Formula (Hill Notation):
C14H15F3N8OS
CAS Number:
Molecular Weight:
400.38
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Technical Service
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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(C1=NC2=C(C(N)=N1)N=NN2C[C@@H]3OCCN(C3)CC4=NC=CS4)F

InChI

1S/C14H15F3N8OS/c15-14(16,17)13-20-11(18)10-12(21-13)25(23-22-10)6-8-5-24(2-3-26-8)7-9-19-1-4-27-9/h1,4,8H,2-3,5-7H2,(H2,18,20,21)/t8-/m1/s1

InChI key

VNLPYEMGHGDRRZ-MRVPVSSYSA-N

Biochem/physiol Actions

PF-04957325 is a cAMP-competitive, potent and selective phosphodiesterase 8 inhibitor (IC50 = 3.05 nM/PDE8A, 0.44 nM/PDE8B, 1 μM/PDE4D with 12-14 nM cAMP; >1 μM/all other PDEs).


pictograms

Flame

signalword

Danger

hcodes

Hazard Classifications

Self-react. C

Storage Class

5.2 - Organic peroxides and self-reacting hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

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Global Trade Item Number

SKUGTIN
PZ0407-25MG04065265932738
PZ0407-5MG04065265932745