Q0380
Quinone Oxidoreductase 2 (NQO2) human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥100 units/mg protein
Synonym(s):
NQO2 human, NRH nitroreductase human, NRH quinone reductase human
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About This Item
Specific activity:
≥100 units/mg protein
Assay:
≥90% (SDS-PAGE)
Recombinant:
expressed in E. coli
recombinant
expressed in E. coli
Quality Segment
assay
≥90% (SDS-PAGE)
form
lyophilized powder (one vial contains one mg protein)
specific activity
≥100 units/mg protein
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... NQO2(4835)
Application
The product from Sigma has been used to identify novel inhibitors of the enzyme NQO2. It has also been used to investigate the effect of afobazole on quinone reductase 2 activity.
Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.
Biochem/physiol Actions
Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.
Unique human oxidoreductase that uses Dihydronicotinamide riboside (NRH) as a cosubstrate, not NAD(P)H. Activates anticancer prodrugs. Putative melatonin receptor.
Physical form
contains 10% PBS buffer salts
Other Notes
One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 °C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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