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Q3638

Quetiapine hemifumarate salt

Name: Quetiapine hemifumarate salt
Brand: SIGMA

≥98% (HPLC), serotonin (5HT2) and dopamine (D2) receptor antagonist, powder

Synonym(s):

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate, Quetiapine fumarate

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₅N₃O₂S · 0.5C₄H₄O₄

CAS Number:

111974-72-2

Molecular Weight:

441.54

UNSPSC Code:

12352200

PubChem Substance ID:

329823864

NACRES:

NA.77

MDL number:

MFCD03423782

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Quetiapine hemifumarate salt, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

SMILES string

OC(=O)\C=C\C(O)=O.OCCOCCN1CCN(CC1)C2=Nc3ccccc3Sc4ccccc24.OCCOCCN5CCN(CC5)C6=Nc7ccccc7Sc8ccccc68

InChI

1S/2C21H25N3O2S.C4H4O4/c2*25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h2*1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+

InChI key

ZTHJULTYCAQOIJ-WXXKFALUSA-N

Gene Information

human ... DRD2(1813), HTR2A(3356), HTR2C(3358)

Description

General description

Quetiapine is a derivative of dibenzothiazepine compound and is also referred to as seroquel and clemastine.

Application

Quetiapine hemifumarate salt has been used as an antagonist for β-arrestin 2 mutant T205M recruitment.

Biochem/physiol Actions

Quetiapine promotes oligodendrogenesis in vitro. It is used in treating depressive disorders.

Quetiapine hemifumarate is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.

Quetiapine hemifumarate is an atypical antipsychotic, a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

GHS07,GHS09

Signal Word

Warning

Storage Class

11 - Combustible Solids

Target Organs

Central nervous system

Hazard Codes

H302,H319,H336,H411

Precautionary Statements

P261 - P264 - P271 - P273 - P301 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT SE 3

Flash Point (°F)

No data available

Flash Point (°C)