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Merck
CN

R0635

Retinyl Acetate-Water Soluble

BioReagent, suitable for cell culture

Synonym(s):

Retinyl acetate, Retinol Acetate, Vitamin A, Retinol acetate, Vitamin A acetate

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About This Item

Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
127-47-9
Molecular Weight:
328.49
NACRES:
NA.75
UNSPSC Code:
12352205
Beilstein/REAXYS Number:
1915439
MDL number:
MFCD00019413

Key Documents

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Product Name

Retinyl Acetate-Water Soluble, BioReagent, suitable for cell culture

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

biological source

synthetic (organic)

product line

BioReagent

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to light yellow

mp

57-58 °C

solubility

H2O: 400 mg/mL

storage temp.

−20°C

Quality Level

200

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Application

Retinyl Acetate-Water Soluble has been used as a component of culture medium for secretory cells of venom gland among different Viperidae snakes. It has also been used in testis chunk culturing.
Use to study retinoid regulation of cell transformation; cell differentiation and stem cell development.

Biochem/physiol Actions

Retinyl acetate is known to prevent carcinogenic polycyclic hydrocarbon, methylcholanthrene induced morphological transformation.

General description

Retinyl acetate does not exists naturally, but is derived from retinol. It is considered to be more chemically stable than retinol. For this reason it serves as a dietary supplement for vitamin A source. Vitamin A is found in food of animal origin especially liver and also present in brightly colored vegetables. Vitamin A is a member of carotene family, which is a key component in plant pigments.

Packaging

Package size based on retinol acetate content

Preparation Note

With a minimum of 3 mg retinol acetate per gram; balance methyl-β-cyclodextrin.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM2402
SLCL0217
SLCH6358
SLCD4128
SLCC7236

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Advanced Nutrition Micronutrie, 23-23 (2018)
Specifications and Criteria for Biochemical Compounds, 1344, 188-188 (1967)
Biological Responses in Cancer: Progress toward Potential Applications, 2, 62-62 (2013)
Long-term primary culture of secretory cells of Bothrops jararaca venom gland for venom production in vitro
Yamanouye N, et al.
Nature Protocols, 1(6), 2763-2763 (2006)
Robert E Chapin et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 107(6), 225-242 (2016-12-27)
The last two decades have seen an increasing search for in vitro models that can replace the use of animals for safety testing. We adapted the methods from a recent nonquantitative report of spermatogenesis occurring in ex vivo mouse testis

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