R121
S(−)-Raclopride (+)-tartrate salt
>97%, Dopamine D2 receptor antagonist, solid
Synonym(s):
3,5-Dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxybenzamide (+)-tartrate salt
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About This Item
Empirical Formula (Hill Notation):
C15H20Cl2N2O3 · C4H6O6
CAS Number:
Molecular Weight:
497.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
S(−)-Raclopride (+)-tartrate salt, >97%, solid
Quality Level
assay
>97%
form
solid
color
white
solubility
H2O: 89 mg/mL
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC
InChI
1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1
InChI key
QULBVRZTKPQGCR-NDAAPVSOSA-N
Gene Information
human ... DRD2(1813)
Application
S(−)-Raclopride (+)-tartrate salt has been used as a D2 receptor antagonist:
- to study the role of the D2 receptor in mediating ventrolateral PAG (vlPAG)/dorsal raphe dopaminergic antinociceptive effect in animals
- in pharmacological and behavioral studies performed with Thap1 null mice
- to determine the relationship between Ca2+ transients and dopamine neuron activity in rats
Biochem/physiol Actions
Raclopride is a benzamide derivative and a selective D2 dopamine receptor antagonist.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Disclaimer
Photosensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Datasheet
H Lublin et al.
Psychopharmacology, 112(2-3), 389-397 (1993-01-01)
The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 23390 (D1 antagonist) was given daily to investigate the direct behavioural
Angel Toval et al.
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J Kopp et al.
Neuroscience, 47(4), 771-779 (1992-01-01)
Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this study we used the dopamine D2 receptor antagonist raclopride
Global Trade Item Number
| SKU | GTIN |
|---|---|
| R121-100MG | 04061832093147 |
| R121-25MG | 04061836694272 |