R123
RBI 257 maleate salt
solid
Synonym(s):
1-[4-Iodobenzyl]-4-[[2-[3-isopropoxy]pyridyl]-methylamino]piperidine maleate salt, p-Iodo-U-101,958 maleate salt
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About This Item
Empirical Formula (Hill Notation):
C21H28IN3O · C4H4O4
Molecular Weight:
581.44
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
form
solid
color
white
solubility
H2O: 0.2 mg/mL
ethanol: 1 mg/mL
0.1 M HCl: 7 mg/mL
DMSO: 9 mg/mL
storage temp.
2-8°C
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)Oc1cccnc1N(C)C2CCN(CC2)Cc3ccc(I)cc3
Biochem/physiol Actions
High affinity D4 dopamine receptor ligand.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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N S Kula et al.
European journal of pharmacology, 331(2-3), 333-336 (1997-07-23)
RBI-257 (1-[4-iodobenzyl]-4-[N-(3-isopropoxy-2-pyridinyl)-N-methyl]-aminopiperid ine), the p-iodobenzyl analog of U-101,958 (1-benzyl-4-[N-(3-isopropoxy-2-pyridinyl)-N-methyl]-aminopiperidine) had a lower dissociation constant (Ki = 0.3 vs. 2.7 nM) and higher selectivity than U-101,958 at dopamine D4 receptors, over dopamine D2 and D3 receptors in transfected cell membranes and
Compounds selective for dopamine receptor subtypes.
Kebabian, et al.
Drug Discovery Today, 2, 333-340 (1997)
F Henry et al.
Theriogenology, 83(8), 1373-1380 (2015-03-05)
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