R1283
Rhodblock 6
≥98% (HPLC)
Synonym(s):
N-1H-Indazol-5-yl-cyclobutanecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C12H13N3O
CAS Number:
Molecular Weight:
215.25
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
GXJXOQKXBIPBKB-UHFFFAOYSA-N
SMILES string
O=C(Nc1ccc2[nH]ncc2c1)C3CCC3
InChI
1S/C12H13N3O/c16-12(8-2-1-3-8)14-10-4-5-11-9(6-10)7-13-15-11/h4-8H,1-3H2,(H,13,15)(H,14,16)
assay
≥98% (HPLC)
form
powder
color
faintly bluish, off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
Quality Level
Related Categories
Biochem/physiol Actions
Rhodblock 6 is an inhibitor of the Rho Kinase pathway.
Rhodblock 6 is an inhibitor of the Rho Kinase pathway. Rhodblock 6 directly inhibited Rok and its human ortholog ROCK I in a kinase assay.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Xavier Fioramonti et al.
Diabetes, 59(2), 519-528 (2009-11-26)
The response of ventromedial hypothalamic (VMH) glucose-inhibited neurons to decreased glucose is impaired under conditions where the counterregulatory response (CRR) to hypoglycemia is impaired (e.g., recurrent hypoglycemia). This suggests a role for glucose-inhibited neurons in the CRR. We recently showed
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