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Merck
CN

R1401

Reversin 205

≥98% (HPLC), film

Synonym(s):

[Boc-Glu(Obzl)]2-Lys-Ome

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About This Item

Empirical Formula (Hill Notation):
C41H58N4O12
CAS Number:
174630-05-8
Molecular Weight:
798.92
NACRES:
NA.47
PubChem Substance ID:
329824002
UNSPSC Code:
12161501
MDL number:
MFCD03788013

Key Documents

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Product Name

Reversin 205, ≥98% (HPLC), film

InChI

1S/C41H58N4O12/c1-40(2,3)56-38(51)44-30(21-23-33(46)54-26-28-16-10-8-11-17-28)35(48)42-25-15-14-20-32(37(50)53-7)43-36(49)31(45-39(52)57-41(4,5)6)22-24-34(47)55-27-29-18-12-9-13-19-29/h8-13,16-19,30-32H,14-15,20-27H2,1-7H3,(H,42,48)(H,43,49)(H,44,51)(H,45,52)/t30-,31-,32-/m0/s1

SMILES string

COC(=O)[C@H](CCCCNC(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)NC(=O)[C@H](CCC(=O)OCc2ccccc2)NC(=O)OC(C)(C)C

InChI key

BRVAQYBFHAIYLQ-CPCREDONSA-N

assay

≥98% (HPLC)

form

film

storage condition

desiccated

color

colorless

mp

101-102 °C

solubility

DMSO or ethanol: soluble (Insoluble in water)

storage temp.

−20°C

Quality Level

100

Gene Information

human ... GRIN2B(2904)
mouse ... GRIN2B(14812)
rat ... GRIN2B(24410)

Related Categories

Biochem/physiol Actions

Peptide chemosensitizer, inhibitor of P-glycoprotein.

General description

Reversin 205 is a hydrophobic peptide.

Application

Reversin 205 has been used to determine the activity of P-glycoprotein in human retinal pigment epithelium.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
101M4721V
110K4704

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Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells.
Sharom FJ
Biochemical Pharmacology, 58(4), 571-586 (1999)
P-glycoprotein expression in human retinal pigment epithelium
Brian G
Molecular Vision, 8 (2002)
Rohini Kondal et al.
Polymers, 13(17) (2021-09-11)
The impact of polymer-based slow-release urea formulations on soil microbial N dynamics in potatoes has been sparingly deciphered. The present study investigated the effect of a biodegradable nano-polymer urea formulation on soil enzymatic activities and microflora involved in the N

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