R1903
RS 102895 hydrochloride
≥98% (HPLC), powder
Synonym(s):
1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one
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About This Item
Empirical Formula (Hill Notation):
C21H21F3N2O2 · HCl
Molecular Weight:
426.86
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Quality Segment
assay
≥98% (HPLC)
form
powder
mol wt
426.86 g/mol
packaging
pkg of 5 mg
storage condition
desiccated
color
white
solubility
DMSO: >10 mg/mL
storage temp.
20-25°C
SMILES string
Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1
InChI
1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
InChI key
KRRISOFSWVKYBF-UHFFFAOYSA-N
General description
RS 102895 hydrochloride is a small molecule antagonist of C-C motif chemokine receptor 2 (CCR2) which belongs to the spiropiperidine (SP) class.
Application
RS 102895 hydrochloride has been used in bromodeoxyuridine (5-bromo-2′-deoxyuridine, BrdU) cell proliferation assay to study effect of IL33 (interleukin 33) on decidual stromal cell proliferation in present of the antagonist and to study the effects of antagonists on the accumulation of bone marrow-derived microglia.
Biochem/physiol Actions
RS 102895 hydrochloride has a high affinity to the β subunit of the C-C motif chemokine receptor 2 (CCR2) and binds specifically to it. This results in the inhibition of CCR2 signaling. It also suppresses monocyte recruitment. Hence, RS 102895 may be useful for obstructing the immune suppressive effects of monocytes during early vaccine responses.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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