R2533
RS-127445 hydrochloride
≥98% (HPLC), powder
Synonym(s):
2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C17H16FN3 · HCl
CAS Number:
Molecular Weight:
317.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥20 mg/mL
originator
Roche
storage temp.
2-8°C
SMILES string
Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
InChI
1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
InChI key
MKJPYBJBPRFMHL-UHFFFAOYSA-N
Biochem/physiol Actions
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist.
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Maximilian Breuer et al.
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| R2533-25MG | 04061836694753 |
| R2533-5MG | 04061836694760 |