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Merck
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R2650

Monoclonal Anti-Rac antibody produced in mouse

clone 23A8, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01634077
Conjugate:
unconjugated
Clone:
23A8, monoclonal
Application:
IHC (f), IP, WB
Citations:
4

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

23A8, monoclonal

form

buffered aqueous solution

mol wt

antigen 21 kDa

species reactivity

rat, human, mouse

technique(s)

immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, western blot: 0.5-2.0 μg/mL using rat brain microsomal protein preparation

isotype

IgG

UniProt accession no.

Q15052

shipped in

dry ice

storage temp.

−20°C

Quality Level

200

Gene Information

human ... ARHGEF6(9459)
mouse ... Arhgef6(73341)
rat ... Arhgef6(363509)

Immunogen

recombinant protein containing the full length human Rac1.

Biochem/physiol Actions

The antibody recognizes Rac1 with a slight Rac2 cross-reactivity.

Physical form

Solution in 0.1 M Tris-glycine, pH 7.4, containing 0.15 M NaCl and 0.05% sodium azide with 30% glycerol.

Preparation Note

Purified using protein G

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBQ0498V
SLBM3392
SLBM1616
SLBG5416
SLBD8580

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Laura Barrio-Real et al.
Oncotarget, 9(47), 28612-28624 (2018-07-10)
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (P-Rex1) is a key mediator of growth factor-induced activation of Rac1, a small GTP-binding protein widely implicated in actin cytoskeleton reorganization. This Guanine nucleotide Exchange Factor (GEF) is overexpressed in human luminal breast cancer
Michael R Dohn et al.
The Journal of cell biology, 184(3), 437-450 (2009-02-04)
p120-catenin regulates epithelial cadherin stability and has been suggested to function as a tumor suppressor. In this study, we used anchorage-independent growth (AIG), a classical in vitro tumorigenicity assay, to examine the role of p120 in a different context, namely
Matthias Rübsam et al.
Nature communications, 8(1), 1250-1250 (2017-11-03)
Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer. This positioning necessitates tissue-level polarization of junctions and the cytoskeleton through unknown mechanisms. Using quantitative whole-mount
Cheng-Wei Lin et al.
Carcinogenesis, 35(11), 2425-2435 (2014-06-28)
Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells

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Data Sheet - R2650

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