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Merck
CN

R2905

Sigma-Aldrich

Anti-RAE1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-MRNP41, Anti-RNA export 1, Anti-mRNA-binding protein 41 kDa

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 43 kDa

species reactivity

human, mouse, rat

concentration

~1.0 mg/mL

technique(s)

western blot: 1-2 μg/mL using 3T3 and RIN5 cell lysates
western blot: 2-4 μg/mL using HEK-293T cell lysate

UniProt accession no.

P78406

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... RAE1(8480)
mouse ... Rae1(66679)
rat ... Rae1(362281)

General description

RAE1 (mRNA export factor 1) is a nucleic acid-binding protein. It is also called as Gle2 (RNA export factor) or mrnp41 (mRNA binding protein mrnp 41). It is located on human chromosome 20q13.

Immunogen

synthetic peptide corresponding to amino acids 349-366 of human RAE1, conjugated to KLH via an N-terminal added cysteine residue. The corresponding sequence is identical in rat and mouse.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

Suppression of RAE1 (mRNA export factor 1) affects the mitotic spindle assembly. It involves in mRNA export as mRNP-interacting protein. In mouse, Rae1 is necessary for early embryogenesis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice
Baker DJ, et al.
The Journal of Cell Biology, 172(4), 529-540 (2006)
The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
Edwards CA, et al.
BMC Evolutionary Biology, 7:157 (2007)
A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly
Blower MD, et al.
Cell, 121(2), 223-234 (2005)
Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 ? Nup98)
Quan B, et al.
Proceedings of the National Academy of Sciences of the USA, 111(25), 9127-9132 (2014)
RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains
Pritchard CE, et al.
The Journal of Cell Biology, 145(2), 237-254 (1999)
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