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R3400

Anti-KRAS Antibody

Name: Anti-KRAS Antibody
Brand: SIGMA

mouse monoclonal, 234-4.2

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About This Item

UNSPSC Code:

12352203

MDL number:

MFCD00239650

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

234-4.2, monoclonal

Application:

IHC (p), IP, WB

Citations:

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Properties

Product Name

Monoclonal Anti-c-K-Ras antibody produced in mouse, clone 234-4.2, purified immunoglobulin, buffered aqueous solution

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

234-4.2, monoclonal

form

buffered aqueous solution

mol wt

antigen 21 kDa

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10 μg/mL using normal skin tissue, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG2κ

UniProt accession no.

P01116

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... KRAS(3845)
mouse ... Kras(16653)
rat ... Kras(24525)

Description

General description

c-K-Ras or KRAS (kirsten rat sarcoma-2 virus oncogene) is a small GTP-binding protein. It is located on human chromosome 12p12.1. KRAS has two splice variants, such as KRASA and KRASB (KRAS proto-oncogenes). Expression of KRASA is restricted to specific tissues whereas KRASB is expressed everywhere .

Immunogen

recombinant p21 protein

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

KRAS (kirsten rat sarcoma-2 virus oncogene) mutation leads to poor prognosis of early rectal cancer.

The antibody reacts with c-K-Ras and v-K-Ras p21. It crossreacts with cH-Ras and cN-Ras p21 on immunoblots.

Physical form

Solution in 0.05 M sodium phosphate buffer, pH7.5, containing 0.2% gelatin and < 0.1% sodium azide

Preparation Note

Purified using protein A or G

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)