R3405
RP-107
≥98% (HPLC), solid
Synonym(s):
7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
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About This Item
Empirical Formula (Hill Notation):
C16H17N3O
CAS Number:
Molecular Weight:
267.33
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: >10 mg/mL
H2O: insoluble
storage temp.
2-8°C
SMILES string
CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
InChI
1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
InChI key
PRIGRJPRGZCFAS-UHFFFAOYSA-N
Biochem/physiol Actions
RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel.
RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC50 = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.
Features and Benefits
This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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