R4278
Anti-phospho-Retinoblastoma (pSer811) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-phospho-Rb (pSer811)
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
technique(s)
western blot: 0.5-1.5 μg/mL using Jurkat cells in high growth phase.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
target post-translational modification
phosphorylation (pSer811)
Gene Information
human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)
General description
Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1). It is located on human chromosome 13q14. It is a tumor suppressor gene.
Immunogen
synthetic phosphopeptide derived from the region of human Rb that contains Ser811.
Biochem/physiol Actions
Retinoblastoma (RB) interacts with several protein factors to control the expression of target genes which promote cell cycle arrest, apoptosis, and differentiation. It helps to modulate nucleosome and chromatin structures. Absence of RB induces prostate cancer metastasis.
Physical form
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.
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存储类别
10 - Combustible liquids