R4278
Anti-phospho-Retinoblastoma (pSer811) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-phospho-Rb (pSer811)
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
technique(s)
western blot: 0.5-1.5 μg/mL using Jurkat cells in high growth phase.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
target post-translational modification
phosphorylation (pSer811)
Gene Information
human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)
General description
Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1). It is located on human chromosome 13q14. It is a tumor suppressor gene.
Immunogen
synthetic phosphopeptide derived from the region of human Rb that contains Ser811.
Biochem/physiol Actions
Retinoblastoma (RB) interacts with several protein factors to control the expression of target genes which promote cell cycle arrest, apoptosis, and differentiation. It helps to modulate nucleosome and chromatin structures. Absence of RB induces prostate cancer metastasis.
Physical form
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.
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Storage Class Code
10 - Combustible liquids
Regulatory Information
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Roles of pRB in the Regulation of Nucleosome and Chromatin Structures
Uchida C, et al.
BioMed Research International (2016)
A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
Patrick J Cimino et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(8), 1073-1087 (2014-01-11)
Merkel cell carcinoma is a highly aggressive cutaneous neuroendocrine tumor that has been associated with Merkel cell polyomavirus in up to 80% of cases. Merkel cell polyomavirus is believed to influence pathogenesis, at least in part, through expression of the
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)
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