生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, mouse, human
技术
western blot: 0.5-1.5 μg/mL using Jurkat cells in high growth phase.
UniProt登记号
运输
dry ice
储存温度
−70°C
靶向翻译后修饰
phosphorylation (pSer811)
基因信息
human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)
一般描述
Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1). It is located on human chromosome 13q14. It is a tumor suppressor gene.
免疫原
synthetic phosphopeptide derived from the region of human Rb that contains Ser811.
生化/生理作用
Retinoblastoma (RB) interacts with several protein factors to control the expression of target genes which promote cell cycle arrest, apoptosis, and differentiation. It helps to modulate nucleosome and chromatin structures. Absence of RB induces prostate cancer metastasis.
外形
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.
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储存分类代码
10 - Combustible liquids
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