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Merck
CN

R4632

Retinyl acetate

synthetic, crystalline solid or supercooled liquid

Synonym(s):

Retinol acetate, Vitamin A acetate

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About This Item

Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
127-47-9
Molecular Weight:
328.49
NACRES:
NA.79
PubChem Substance ID:
57654592
eCl@ss:
34058009
UNSPSC Code:
12352205
EC Number:
204-844-2
MDL number:
MFCD00019413
Beilstein/REAXYS Number:
1915439

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Product Name

Retinyl acetate, synthetic, crystalline solid or supercooled liquid

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

biological source

synthetic

assay

≥90% (HPLC)

form

crystalline solid or supercooled liquid

potency

2,600,000-2,940,000 I.U. per g

color

light yellow to dark yellow

mp

57-58 °C
~58 °C (lit.)

storage temp.

−20°C

Quality Level

300

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Analysis Note

Activity based on HPLC comparison to USP standard.

Application

Retinyl acetate has been used:
  • to study its effects on cochlear development in mice
  • as a component of an internal standard to quantify antioxidants in yolk
  • as an internal standard to determine serum retinol concentration

Biochem/physiol Actions

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinyl acetate is used in a wide range of biological applications.

General description

Vitamin A usually occurs in food as retinyl esters, which are the pre-formed sources of vitamin A. Retinyl acetate exists as yellow crystals and is insoluble in water. It is soluble in ethanol and oils.

Physical form

Packaged as a melt and may exist as a crystalline solid or a supercooled viscous liquid

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF8016V
MKCZ9208
WXBF7404V
WXBF5643V
WXBF4633V

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Capillary electrophoresis Food Additives
Frazier RA
Encyclopedia of Separation Science (2007)
The common marmoset in captivity and biomedical research
Marini RP
Common Fragrance and Flavor Materials (2018)
Buhler Volker
Vademecum for Vitamin Formulations (2001)
Effects of retinoid treatment on cochlear development, connexin expression and hearing thresholds in mice
Kim Yy, et al.
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-rhino-laryngologie et de Chirurgie Cervico-Faciale (2018)
Assessment of the relative dose-response test based on serum retinol-binding protein instead of serum retinol in determining low hepatic vitamin A stores
Fujita M, et al.
American Journal of Clinical Nutrition (2009)
View All Related Papers

Protocols

HPLC Determination of Vitamin A and E

GB method with Ascentis® Express C30 column achieves baseline resolution for Vitamin A and E critical pair.

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