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R5655

Rebamipide hydrate

≥98% (HPLC), COX-2 activator, powder

Synonym(s):

α-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid hydrate, Mucosta hydrate, OPC 12759 hydrate, Proamipide hydrate

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About This Item

Empirical Formula (Hill Notation):
C19H15ClN2O4 · xH2O
CAS Number:
90098-04-7
Molecular Weight:
370.79 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329824033
NACRES:
NA.77
MDL number:
MFCD11114396
Assay:
≥98% (HPLC)
Form:
powder
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Product Name

Rebamipide hydrate, ≥98% (HPLC), powder

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >5 mg/mL

SMILES string

O.OC(=O)C(CC1=CC(=O)Nc2ccccc12)NC(=O)c3ccc(Cl)cc3

InChI

1S/C19H15ClN2O4.H2O/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15;/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26);1H2

InChI key

WQRHVBKNEDPECA-UHFFFAOYSA-N

Biochem/physiol Actions

Rebamipide helps to reduce intestinal injury, stimulated by radiation.
Rebamipide hydrate is an anti-ulcer agent, an antioxidant, a gastrointestinal agent, and a gastric cytoprotectant.
Rebamipide is an anti-ulcer agent with free-radical scavenging and anti-inflammatory effects. It has been used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating COX-2 genes. Rebamipide significantly reduced ulcerogenesis and maintained mucosal superoxide dismutase (SOD) activity. It has also been used for the treatment of Behçet′s disease. Rebamipide may be involved in a noval mechanism to enhance tear secretion and increase mucin levels covering conjunctiva and cornea.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Codes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type N95 (US)

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