R5655
Rebamipide hydrate
≥98% (HPLC), COX-2 activator, powder
别名:
α-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid hydrate, Mucosta hydrate, OPC 12759 hydrate, Proamipide hydrate
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关于此项目
经验公式（希尔记法）:
C19H15ClN2O4 · xH2O
化学文摘社编号:
分子量:
370.79 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Rebamipide hydrate, ≥98% (HPLC), powder
SMILES string
O.OC(=O)C(CC1=CC(=O)Nc2ccccc12)NC(=O)c3ccc(Cl)cc3
InChI key
WQRHVBKNEDPECA-UHFFFAOYSA-N
InChI
1S/C19H15ClN2O4.H2O/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15;/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26);1H2
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: >5 mg/mL
Quality Level
Biochem/physiol Actions
Rebamipide hydrate is an anti-ulcer agent, an antioxidant, a gastrointestinal agent, and a gastric cytoprotectant.
Rebamipide is an anti-ulcer agent with free-radical scavenging and anti-inflammatory effects. It has been used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating COX-2 genes. Rebamipide significantly reduced ulcerogenesis and maintained mucosal superoxide dismutase (SOD) activity. It has also been used for the treatment of Behçet′s disease. Rebamipide may be involved in a noval mechanism to enhance tear secretion and increase mucin levels covering conjunctiva and cornea.
Rebamipide helps to reduce intestinal injury, stimulated by radiation.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type N95 (US)
Rebamipide ameliorates radiation-induced intestinal injury in a mouse model
Shim S, et al.
Toxicology and Applied Pharmacology, 329, 40-47 (2017)
Fumiaki Nagashima et al.
Biomolecules & therapeutics, 26(4), 399-408 (2017-12-11)
In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the transport of [3H]choline, and explored the possible correlation between the
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