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R5903

Anti-Rab11 antibody produced in rabbit

1 mg/mL, affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01322583
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
rat, mouse, human
Citations:
12
Technique(s):
western blot: 6.6 μg/mL using HeLa cell extract
Uniprot accession no.:
P62491

Key Documents

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Product Name

Anti-Rab11 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

concentration

1 mg/mL

technique(s)

western blot: 6.6 μg/mL using HeLa cell extract

UniProt accession no.

P62491

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... RAB11A(8766)
mouse ... Rab11a(53869)
rat ... Rab11a(81830)

Biochem/physiol Actions

Rab11a (Ras-related protein Rab-11A) participates in the modulation of basolateral to apical transcytosis. It controls TRPV5/6 (Ca2+-selective members) channel trafficking. It is essential for the production of bile canalicular in WIF-B9 cells (rat hepatoma/human fibroblast hybrid cells).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Application

Anti-Rab11 has been used in western blotting and immunohistochemistry.

General description

Rab11 (Ras-related protein) has three subtypes -Rab11a, Rab11b, and Rab25. Rab11a (Ras-related protein Rab-11A) belongs to the ras-like small GTP-binding protein superfamily. It is found in nonpolarized cells like fibroblasts and erythroleukemia cells. It is located on human chromosome 15q21.3-q22.31 and on mouse chromosome 9. Rab11a is expressed abundantly.

Immunogen

synthetic peptide corresponding to amino acid residues 1-17 from human Rab11. This sequence is completely conserved in human, mouse, and rat and 94% conserved in C. elegans and amphibians.

Physical form

Solution in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBM8943
SLBD5300
031M1852
110M1988
058K1583

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Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells
Kallquist L, et al.
Experimental Cell Research, 316(19), 3182-3196 (2010)
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function
Muller J, et al.
PLoS ONE, 9(2) (2014)
Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins
Gromov PS, et al.
Febs Letters, 429(3), 359-364 (1998)
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes
Husebye H, et al.
Immunity, 33(4), 583-596 (2010)
Regulation of vesicle trafficking in madin-darby canine kidney cells by Rab11a and Rab25
Wang X, et al.
The Journal of Biological Chemistry, 275(37), 29138-29146 (2000)
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Data Sheet - R5903

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