Anti-phospho-Retinoblastoma (pSer^807,811) antibody produced in rabbit

RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.

synthetic peptide corresponding to residues around phosphoserine 807/811 of the human retinoblastoma tumor suppressor protein (Rb), conjugated to KLH.

Anti-phospho-Retinoblastoma (pSer807,811) has been used in western blotting.

RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.

Recognizes phosphorylated Rb (Ser⁸⁰⁷/Ser⁸¹¹) and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.

Purified using protein A and peptide affinity chromatography.

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