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Merck
CN

R6527

Reboxetine mesylate hydrate

>96% (HPLC), noradrenaline uptake inhibitor, solid

Synonym(s):

(2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine, Edronax, Vestra

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About This Item

Empirical Formula (Hill Notation):
C19H23NO3 · CH3SO3H · xH2O
CAS Number:
98769-84-7
Molecular Weight:
409.50 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24724592
NACRES:
NA.77
MDL number:
MFCD11046031

Key Documents

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Product Name

Reboxetine mesylate hydrate, >96% (HPLC), solid

SMILES string

O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3

InChI key

SZPHEVAYLIVGRC-BAMQSBMESA-N

InChI

1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1

assay

>96% (HPLC)

form

solid

storage condition

desiccated

color

white to tan

solubility

H2O: >5 mg/mL at ≤60 °C

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Related Categories

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Application

Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
  • to study its effects on the surge of dopamine in the cortex of mice brain
  • to study its anti-immobility effects on the behavior of mice
  • to analyze its effects on the probabilistic reversal learning task in rodents

Biochem/physiol Actions

Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.
Reboxetine exhibits anti-depressant activity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000183815
0000183816
0000178219
0000178219
081M4620V

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Özgür Devrim Can et al.
European journal of pharmacology, 699(1-3), 250-257 (2012-10-27)
The present study was designed to investigate the putative effect of vitexin, a flavone C-glucoside present in some drugs, medicinal plants and nutraceuticals, on the central nervous system. Vitexin (10-30 mg/kg) did not show significant alterations in the behaviour of
Matthew P Wilkinson et al.
Brain and neuroscience advances, 4, 2398212820907177-2398212820907177 (2020-03-29)
Deficits in reward processing are a central feature of major depressive disorder with patients exhibiting decreased reward learning and altered feedback sensitivity in probabilistic reversal learning tasks. Methods to quantify probabilistic learning in both rodents and humans have been developed
Dennis K Miller et al.
The Journal of pharmacology and experimental therapeutics, 302(2), 687-695 (2002-07-20)
The present study determined whether repeated administration of the antidepressant and selective norepinephrine (NE) uptake inhibitor reboxetine resulted in an adaptive modification of the function of the NE transporters (NETs), serotonin (5-HT) transporters, or dopamine (DA) transporters. Because antidepressants may
Patrick Neiens et al.
Biomedical chromatography : BMC, 32(7), e4231-e4231 (2018-03-04)
MS Binding Assays represent a label-free alternative to radioligand binding assays. In this study, we present an LC-ESI-MS/MS method for the quantification of (R,R)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [(R,R)-D-84, (R,R)-1], (S,S)-reboxetine [(S,S)-2], and (S)-citalopram [(S)-3] employed as highly selective nonlabeled reporter ligands in MS
Hagar Gelbard-Sagiv et al.
Current biology : CB, 28(14), 2239-2249 (2018-07-10)
An identical sensory stimulus may or may not be incorporated into perceptual experience, depending on the behavioral and cognitive state of the organism. What determines whether a sensory stimulus will be perceived? While different behavioral and cognitive states may share
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