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R6527

Reboxetine mesylate hydrate

>96% (HPLC), noradrenaline uptake inhibitor, solid

Synonym(s):

(2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine, Edronax, Vestra

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About This Item

Empirical Formula (Hill Notation):
C19H23NO3 · CH3SO3H · xH2O
CAS Number:
98769-84-7
Molecular Weight:
409.50 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24724592
NACRES:
NA.77
MDL number:
MFCD11046031
Assay:
>96% (HPLC)
Form:
solid
Storage condition:
desiccated
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Product Name

Reboxetine mesylate hydrate, >96% (HPLC), solid

Quality Segment

assay

>96% (HPLC)

form

solid

storage condition

desiccated

color

white to tan

solubility

H2O: >5 mg/mL at ≤60 °C

shipped in

wet ice

storage temp.

2-8°C

SMILES string

O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3

InChI

1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1

InChI key

SZPHEVAYLIVGRC-BAMQSBMESA-N

Application

Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
  • to study its effects on the surge of dopamine in the cortex of mice brain
  • to study its anti-immobility effects on the behavior of mice
  • to analyze its effects on the probabilistic reversal learning task in rodents

Biochem/physiol Actions

Reboxetine exhibits anti-depressant activity.
Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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