R7532
RRD-251 hydrochloride
≥98% (HPLC)
Synonym(s):
(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride, 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride, Rb/Raf-1 disruptor 251 hydrochloride, S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C8H8Cl2N2S· HCl
CAS Number:
Molecular Weight:
271.59
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: >10 mg/mL, H2O: >2 mg/mL
storage temp.
room temp
SMILES string
Cl.NC(=N)SCc1ccc(Cl)cc1Cl
InChI
1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI key
COMNQRICZGJVLE-UHFFFAOYSA-N
Biochem/physiol Actions
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction.
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| R7532-5MG | 04061833066379 |
| R7532-25MG | 04061833066362 |