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Merck
CN

R9400

Monoclonal Anti-RANTES antibody produced in rat

clone 53405.111, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-D17S136E, Anti-RANTES, Anti-SCYA5, Anti-SIS-delta, Anti-SISd, Anti-TCP228, Anti-eoCP

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD01635727
Conjugate:
unconjugated
Clone:
53405.111, monoclonal
Application:
ICC, Neutral
Citations:
4

Key Documents

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biological source

rat

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

53405.111, monoclonal

form

lyophilized powder

purified by

using protein G

species reactivity

mouse

technique(s)

immunocytochemistry: 8-25 μg/mL using mouse splenocytes, neutralization: suitable

isotype

IgG2a

UniProt accession no.

P30882

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Ccl5(20304)

Immunogen

purified, E. coli-derived, recombinant mouse RANTES.

Biochem/physiol Actions

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose pH 7.4.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ8151
MKCQ2123
MKCN7061
MKCN5336
MKCM4372

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Alan M Krensky et al.
Nature clinical practice. Nephrology, 3(3), 164-170 (2007-02-27)
Chemokines (chemoattractant cytokines) are fundamental regulators of immune cell movement from the bloodstream into tissues. Regulating expression of chemokines might, therefore, alleviate inflammation in autoimmune diseases and transplant rejection, or augment immune responses in cancer and immunodeficiency. RANTES (regulated upon
V Appay et al.
Trends in immunology, 22(2), 83-87 (2001-04-05)
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some
The unexpected pleiotropic activities of RANTES.
Jay A Levy
Journal of immunology (Baltimore, Md. : 1950), 182(7), 3945-3946 (2009-03-21)
F Villalta et al.
Infection and immunity, 66(10), 4690-4695 (1998-09-24)
This paper describes a new role for the cysteine-cysteine (CC) chemokines RANTES, MIP-1alpha, and MIP-1beta on human macrophage function, which is the induction of nitric oxide (NO)-mediated trypanocidal activity. In a previous report, we showed that RANTES, MIP-1alpha and MIP-1beta

Related Content

Data Sheet - R9400

Instructions

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