RAB0282
Equine Interleukin-1 Receptor Antagonist / IL-1F3 ELISA Kit
for serum, plasma and cell culture supernatant
Synonym(s):
IL-1ra
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
species reactivity
equine
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type cell culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/mL
standard curve range: 12.29-3000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
equine ... IL1RN(100034236)
General description
The Equine IL-1ra (interleukin 1 receptor antagonist) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of equine IL-1ra in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Equine IL-1 Receptor Antagonist
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively binding to their type I and type II receptors. IL-1RA plays a vital role in inhibition of acute pro-inflammatory response and forbidding chronic inflammation from damaging healthy tissues. Abnormal expression of IL-1RA leads to development of inflammatory or autoimmune related diseases. Allelic polymorphism of IL-1Rα leads to inflammatory bowel disease (IBD). Therapeutically, IL-1Rα may help in the treatment of sepsis, rheumatoid arthritis, asthma. Overexpression of IL-1Rα is observed in serum of psoriatic arthritis (PsA) patients.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Description
SDS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Regulatory Information
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Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium.
Sousa A R, et al.
American Journal of Respiratory and Critical Care Medicine, 154(4 Pt 1), 1061-1066 (1996)
Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock.
Arnalich F, et al.
The Journal of Infectious Diseases, 180(3), 908-911 (1999)
Serum levels of IL-10, IL-6, IL-1ra, and sIL-2R in patients with psoriatic arthritis.
Elkayam O, et al.
Rheumatology International, 19(3), 101-105 (2000)
Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.
Bioque G, et al.
Clinical and Experimental Immunology, 102(2), 379-383 (1995)
A novel association between IL1-Ra (receptor antagonist) gene polymorphism and T1DM in Al-Madina Al-Mounawra.
Ali R a, et al.
European Review for Medical and Pharmacological Sciences, 19(19), 3701-3708 (2015)
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Instructions
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