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Merck
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RAB0365

Human MMP-2 ELISA Kit

for serum, plasma, cell culture supernatant

Synonym(s):

MMP-2, Matrix metalloproteinase-2

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

Key Documents

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species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 3,500 pg/mL
standard curve range: 3.3-800 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MMP2(4313)

Related Categories

General description

The Human MMP-2 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human MMP-2 in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human MMP2

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human MMP-2 ELISA kit has been used for the determination of MMP-2 in serum samples and cell supernatant.
Human MMP-2 ELISA Kit has been used in ELISA (enzyme-linked immunosorbent assay).

Biochem/physiol Actions

Matrix metalloproteinases (MMPs) enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, which has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. High levels of MMP-2 are observed in the acute phase of transverse myelitis. It is upregulated in colorectal carcinoma and is associated with poor survival outcome. MMP-2 gene haplotypes are also linked with risk of thoracic aortic dissection, a cardiovascular disorder with high death rate.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABELADEELISA 5X Assay/Sample Diluent Buffer E (Item E2)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8B - Non-combustible corrosive hazardous materials

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料
易制毒化学品（3类）
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0313K0170
0502K0170
1122J0170
1005J0170
0315I0170

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Active matrix metalloprotease-9 is associated with the collagen capsule surrounding the Madurella mycetomatis grain in mycetoma.
Geneugelijk K
PLoS Neglected Tropical Diseases, 8, e2754-e2754 (2014)
IL-33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-?B pathway.
Zhang JF
Oncology Reports, 38, 2033-2033 (2017)
Matrix metalloproteinases: role in skeletal development and growth plate disorders.
Malemud CJ
Frontiers in Bioscience, 11, 1702-1715 (2006)
IL-33 enhances glioma cell migration and invasion by upregulation of MMP2 and MMP9 via the ST2-NF-kappaB pathway
Zhang J F, et al.
Oncology Reports, 38(4), 2033-2042 (2017)
Hyperhomocysteinemia is associated with decreased apolipoprotein AI levels in normal healthy people.
Wang Y, et al.
BMC Cardiovascular Disorders, 16, 10-10 (2016)
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