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Merck
CN

RAB0558

Mouse Esm1 / Endothelial Cell-specific Molecule 1 ELISA Kit

for serum, plasma and cell culture supernatants

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About This Item

NACRES:
NA.32
UNSPSC Code:
41116158

Key Documents

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Product Name

Mouse Esm1 / Endothelial Cell-specific Molecule 1 ELISA Kit, for serum, plasma and cell culture supernatants

species reactivity

mouse

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 0.1 ng/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Esm1(71690)

Related Categories

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Endothelial cell-specific molecule 1 (ESM1) may have a role in inflammation and angiogenesis. It has been linked to tumor growth. ESM1 stimulates vascular sprouting, growth, differentiation, migration and adhesion of cells.

General description

This ELISA antibody pair detects mouse Endothelial Cell-specific Molecule 1. Endothelial cell-specific molecule 1 (ESM1) is a secreted dermatan sulfate proteoglycan. This cysteine-rich protein is expressed in kidney glomeruli, specifically in renal epithelia and endothelial cells. Proangiogenic factors and cytokines modulate its activity.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
1203F0530
0903H0530
1030F0530
0421D0530

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Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.
Rocha SF
Circulation Research (2014)
ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma.
Chen C
Oncotarget (2016)
The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction.
Yassine H
Oncotarget (2015)
Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1).
Cong R
Biochemical and Biophysical Research Communications (2006)
Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy.
Zheng X
PLoS ONE (2017)

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