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Merck
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RAB0631

Human C5a / Complement C5a ELISA Kit

for serum, plasma, and cell culture supernatants

Synonym(s):

Complement C5a

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About This Item

NACRES:
NA.32
UNSPSC Code:
41116158

Key Documents

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Product Name

Human C5a / Complement C5a ELISA Kit, for serum, plasma, and cell culture supernatants

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 31 pg/mL
standard curve range: 31.25-2000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... C5(727)

Related Categories

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

General description

Human complement 5a (C5a) is generated during complement activation from the α-chain of complement C5. It binds to a signaling G-protein coupled receptor (GPCR), inducing neutrophil chemotaxis and endothelial cell activation. C5a also triggers an oxidative burst in macrophages and neutrophils and induces release of histamine in basophils and mast cells.
The antibody pair provided in this kit recognizes human Complement Component C5a.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
低风险生物材料
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Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0508K0017
1005H0017
0713I0017
1105F0017
SAMPLE

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Immune Responses to Biosurfaces: Mechanisms and Therapeutic Interventions (2015)
Molecular and expression analysis of complement component C5 in the nurse shark (Ginglymostoma cirratum) and its predicted functional role.
Matthew G, et al.
Fish & Shellfish Immunology, 27(1), 40-49 (2009)
New developments in C5a receptor signaling
Sarma J V and Peter A W
Cell health and cytoskeleton, 4, 73-82 (2012)
Complement System Part II: Role in Immunity
Nicolas S M, et al.
Frontiers in Immunology, 6, 257-257 (2015)
Frédéric Lavainne et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(6), 1225-1231 (2014-02-12)
Soluble Flt1 (sFlt1) is a potent inhibitor of vascular endothelial growth factor, secreted mainly by the placenta, endothelial cells and monocytes. Increased sFlt1 serum levels correlate with endothelial dysfunction and cardiovascular complications in dialysis patients. However, the impact of dialysis
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