RAB0707
Human LDLR / Low-density Lipoprotein Receptor ELISA Kit
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About This Item
NACRES:
NA.32
UNSPSC Code:
41116158
storage temp.
−20°C
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/mL
standard curve range: 8.19-2000 pg/mL
detection method
colorimetric
shipped in
wet ice
Gene Information
human ... LDLR(3949)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
LDLR′s (low density lipoprotein receptor) major function is to regulate the level of lipoprotein particles by mediating the clearance of LDL-cholesterol and triglyceride through receptor mediated endocytosis. LDLR is involved in proliferation by providing cholesterol for membrane synthesis. The LDLR gene is a target for treating cardiovascular diseases. Mutation in the gene causes familial hypercholesterolemia.
General description
The antibody pair provided in this kit recognizes human Low-density Lipoprotein Receptor.
LDLR (low density lipoprotein receptor) codes for a transmembrane receptor glycoprotein, containing 860 amino acids and is mapped to human chromosome 19p13.2.
LDLR (low density lipoprotein receptor) codes for a transmembrane receptor glycoprotein, containing 860 amino acids and is mapped to human chromosome 19p13.2.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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E Soemirien Kasanmoentalib et al.
Journal of neuroinflammation, 16(1), 279-279 (2019-12-31)
The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is a complement regulatory protein inhibiting alternative
Frank Guarnieri et al.
PloS one, 14(12), e0225780-e0225780 (2019-12-06)
PCSK9 is a protein secreted by the liver that binds to the low-density lipoprotein receptor (LDLR), causing LDLR internalization, decreasing the clearance of circulating LDL particles. Mutations in PCSK9 that strengthen its interactions with LDLR result in familial hypercholesterolemia (FH)
A novel indel variant in LDLR responsible for familial hypercholesterolemia in a Chinese family.
Shu H, et al.
PLoS ONE, 12(12), e0189316-e0189316 (2017)
Daniel S Hsia et al.
The British journal of nutrition, 124(6), 577-585 (2020-04-18)
Cranberries are high in polyphenols, and epidemiological studies have shown that a high-polyphenol diet may reduce risk factors for diabetes and CVD. The present study aimed to determine if short-term cranberry beverage consumption would improve insulin sensitivity and other cardiovascular
Mutational screening in the LDLR gene among patients presenting familial hypercholesterolemia in the Southeast of Brazil.
Molfetta G A, et al.
Genetics and molecular research : GMR, 16(3) (2017)
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