RAB0960
Phosphotyrosine FER / Tyrosine-protein Kinase Fer ELISA Kit
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type: human cell lysate
assay range
inter-assay cv: <10%
intra-assay cv: <12%
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FER(2241)
General description
FER (fps/fes related) tyrosine kinase is encoded by the gene mapped to human chromosome 5q21.3. Tyrosine kinase is a cytoplasmic protein characterized with a single SH2 domain and an extensive amino terminus. The encoded protein is ubiquitously expressed.
The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-FER.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
FER tyrosine kinase induces signal transduction at the plasma membrane. It is implicated in the regulation of cell-cell adhesion. FER tyrosine kinase interacts with phosphatidic acid (PA) to enhance phosphorylation of cortactin, a protein that promotes actin.
Kit Components Also Available Separately
Product No.
Description
SDS
- RABHRP6Phosphotyrosine ELISA HRP-Streptavidin
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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The Tyrosine Kinase Fer Is a Downstream Target of the PLD-PA Pathway that Regulates Cell Migration
Itoh T, et al.
Science Signaling, 2(87), ra52-ra52 (2009)
Characterization of a de novo balanced translocation in a patient with moderate mental retardation and dysmorphic features
Haddad M R, et al.
European Journal of Medical Genetics, 52(4), 211-217 (2009)
The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.
Kim L and Wong T W
Molecular Cell Biology, 15(8), 4553-4561 (1995)
A curvature-dependent membrane binding by tyrosine kinase Fer involves an intrinsically disordered region.
Yamamoto H, et al.
Biochemical and Biophysical Research Communications, 495(1), 1522-1527 (2018)
Naoko Kogata et al.
Molecular biology of the cell, 14(9), 3553-3564 (2003-09-16)
Platelet endothelial adhesion molecule-1 (PECAM-1) is a part of intercellular junctions and triggers intracellular signaling cascades upon homophilic binding. The intracellular domain of PECAM-1 is tyrosine phosphorylated upon homophilic engagement. However, it remains unclear which tyrosine kinase phosphorylates PECAM-1. We
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Instructions
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