RAB1050
Human Galectin-8 ELISA Kit
for cell culture supernatants, plasma, and serum samples
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About This Item
NACRES:
NA.32
UNSPSC Code:
41116158
Gene information:
human ... LGALS8(3964)
Input:
sample type plasma
sample type serum sample(s)
sample type cell culture supernatant(s)
sample type serum sample(s)
sample type cell culture supernatant(s)
Species reactivity:
human
Storage temp.:
−20°C
Shipped in:
wet ice
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type plasma
sample type serum sample(s)
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.16 ng/ml
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... LGALS8(3964)
General description
This ELISA antibody pair detects Human Galectin-8 (LGALS8)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Galectin-8 (Gal-8) is a member of “tandem-repeat” galectin family, possesses two carbohydrate binding domains linked by a short peptide. The short peptide accounts for Gal-8 cell adhesion and downstream signalling. Tumor cells, as well as normal tissues, express Gal-8. The expression level of Gal-8 is higher in multiple myeloma conditions and enhances adhesion to vascular endothelium. Galectin-8 binds to integrin selectively and inhibits cell adhesion and promotes apoptosis. Gal-8 interacts with integrin alpha and regulates neutrophil adhesion to endothelial cells and migration. Gal-8 ligand binds to cluster of differentiation 44 (CD44) and causes an inflammatory response in rheumatoid arthritis. Overexpression of Gal-8 plays a key role in metastasis of prostate cancer and cell survival by causing rearrangement of the cytoskeleton and E-cadherin expression.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis
Hadari YR, et al.
Journal of Cell Science, 113(13), 2385-2397 (2000)
Galectin-8 modulates neutrophil function via interaction with integrin alphaM
Nishi N, et al.
Glycobiology, 13(11), 755-763 (2003)
Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer
Gentilini LD, et al.
Oncotarget, 8(27), 44654-44668 (2017)
The involvement of CD44 and its novel ligand galectin-8 in apoptotic regulation of autoimmune inflammation
Sebban LE, et al.
Journal of Immunology, 179(2), 1225-1235 (2007)
Galectin-8 enhances adhesion of multiple myeloma cells to vascular endothelium and is an adverse prognostic factor
Friedel M, et al.
Glycobiology, 26(10), 1048-1058 (2016)
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