RAB1124
Mouse Gremlin-1 ELISA Kit
for cell culture supernatants, plasma, and serum samples
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About This Item
NACRES:
NA.32
UNSPSC Code:
41116158
Gene information:
mouse ... Grem1(23892)
Input:
sample type serum sample(s)
sample type cell culture supernatant(s)
sample type plasma
sample type cell culture supernatant(s)
sample type plasma
Species reactivity:
mouse
Storage temp.:
−20°C
Shipped in:
wet ice
species reactivity
mouse
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type serum sample(s)
sample type cell culture supernatant(s)
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.8 ng/ml
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Grem1(23892)
General description
Gremlin-1 (GREM1) is part of the secreted, cysteine knot DAN family of bone morphogenetic protein antagonists. It has a molecular weight of 24–26kDa.
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Biochem/physiol Actions
Gremlin-1 (GREM1) has a role in embryogenesis. It also has a role in cell functions during development. GREM1 acts as an antagonist of bone morphogenetic proteins (BMP). The protein influences chondrogenesis, outgrowth and apoptosis in limb bud development and has a role in kidney formation. It inhibits the activity of BMP2 and BMP4. GREM1 is involved in angiogenesis, bone formation, bone mass and pulmonary hypertension. Knockout of this gene in mice leads to developmental abnormalities.
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease
Roxburgh SA, et al.
Diabetes, 58(7), 1641-1650 (2009)
Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice.
Ciuclan L, et al.
The American Journal of Pathology, 183(5), 1461-1473 (2013)
Gremlin1 plays a key role in kidney development and renal fibrosis.
Church RH, et al.
American Journal of Physiology: Renal Physiology, 312(6), F1141-F1157 (2017)
Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts.
Liukun Meng et al.
Journal of the American Heart Association, 9(15), e016586-e016586 (2020-08-05)
Background Heterozygous mutation in BMP (bone morphogenetic protein) receptor 2 is rare, but BMP cascade suppression is common in congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH); however, the underling mechanism of BMP cascade suppression independent of BMP receptor 2 mutation
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