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Merck
CN

RES1164B-A7

BIS-TRIS hydrochloride

Synonym(s):

BIS-TRIS hydrochloride, 2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol, Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane

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About This Item

Empirical Formula (Hill Notation):
C8H19NO5 · HCl
CAS Number:
124763-51-5
Molecular Weight:
245.70
MDL number:
MFCD00171252
UNSPSC Code:
12161705
NACRES:
NA.21

Key Documents

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biological source

synthetic

Quality Level

400

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin and microbial; tested

useful pH range

5.8-7.2

pKa 

6.5

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES string

Cl.OCCN(CCO)C(CO)(CO)CO

InChI

1S/C8H19NO5.ClH/c10-3-1-9(2-4-11)8(5-12,6-13)7-14;/h10-14H,1-7H2;1H

InChI key

VEYRVLHAMHQVTC-UHFFFAOYSA-N

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General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Application

Bis Tris HCl is a commonly used biological buffer for very broad usage in biological systems such as diagnostics, electrophoresis and protein based bioprocessing. The pKa of Bis Tris is 6.36, which makes it a good candidate for biological-based formulations.

Bis Tris HCl can be used in a wide variety of biological applications including culture media, electrophoresis separations and diagnostic reagent formulations.

Packaging

Product is available in the following package sizes:
RES1164B-A701X: 100 gm container
RES1164B-A702X: 1 kg container
RES1164B-A704X: 10 kg container

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
CDBG4216
CDBG4222
CDBG4217
CDBG2850
CDBG2831

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