S0278
(±)-Sotalol hydrochloride
≥98% (TLC), powder, β-Adrenoceptor antagonist
Synonym(s):
N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H20N2O3S · HCl
CAS Number:
Molecular Weight:
308.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
213-496-0
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Product Name
(±)-Sotalol hydrochloride, ≥98% (TLC), powder
Quality Segment
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: 20 mg/mL
originator
Bayer
SMILES string
Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
InChI
1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChI key
VIDRYROWYFWGSY-UHFFFAOYSA-N
Gene Information
human ... ADRB1(153), ADRB2(154), ADRB3(155), KCNH2(3757)
Application
(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.
Biochem/physiol Actions
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.
Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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