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S0292

Silymarin

Name: Silymarin
Brand: SIGMA

flavonolignans

Synonym(s):

flavolignans

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About This Item

CAS Number:

65666-07-1

UNSPSC Code:

12352202

NACRES:

NA.81

MDL number:

MFCD01776359

Form:

powder

Biological source:

plant (Silybum marianum)

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biological source

plant (Silybum marianum)

Quality Level

200

form

powder

technique(s)

toxicology assay: suitable

application(s)

microbiology

storage temp.

−20°C

SMILES string

O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO

InChI

1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

InChI key

SEBFKMXJBCUCAI-UHFFFAOYSA-N

General description

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

Application

Silymarin has been used to study:

its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity
its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model
its effect on liver toxication induced by Fumonisin B1 in mice

Biochem/physiol Actions

Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.

Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.

Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.

Other Notes

Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Silymarin suppresses HepG2 hepatocarcinoma cell progression through downregulation of Slit-2/Robo-1 pathway.

Nuriye Ezgi Bektur Aykanat et al.

Pharmacological reports : PR, 72(1), 199-207 (2020-02-06)

14 million people are diagnosed with new cancer and approximately 8 million people die from cancer every year. Hepatocellular carcinoma is the most common type of liver cancer and covers almost 5-6% of cancer deaths worldwide. Silybum marianum, a plant

Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice

Sozmen M, et al.

Journal of Veterinary Science, 15(1), 51-60 (2012)

Multitargeted therapy of cancer by silymarin

Ramasamy K and Agarwal R

Cancer letters, 269(2), 352-362 (2008)

Formulation of Nanomicelles to Improve the Solubility and the Oral Absorption of Silymarin.

Vieri Piazzini et al.

Molecules (Basel, Switzerland), 24(9) (2019-05-06)

Two novel nanomicellar formulations were developed to improve the poor aqueous solubility and the oral absorption of silymarin. Polymeric nanomicelles made of Soluplus and mixed nanomicelles combining Soluplus with d-α-tocopherol polyethylene glycol 1000 succinate (vitamin E TPGS) were prepared using

Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model

Eser N, et al.

Phytomedicine, 19(8-9), 840-845 (2012)

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Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

Global Trade Item Number

SKU	GTIN
S0292-50G	04061835558995
S0292-10G	04061836830199

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