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Merck
CN

S1013

(−)-Scopolamine hydrochloride

≥90% (HPLC), powder

Synonym(s):

Hyoscine hydrochloride, Scopine tropate

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About This Item

Empirical Formula (Hill Notation):
C17H21NO4 · HCl
CAS Number:
Molecular Weight:
339.81
EC Number:
200-225-6
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
4168778
MDL number:
Assay:
≥90% (HPLC)
Form:
powder
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assay

≥90% (HPLC)

form

powder

optical activity

[α]25/D ~−27°, c = 1 in H2O(lit.)

color

white

solubility

H2O: 50 mg/mL

SMILES string

Cl.[H][C@]12C[C@H](C[C@]([H])(N1C)[C@]3([H])O[C@]23[H])OC(=O)[C@H](CO)c4ccccc4

InChI

1S/C17H21NO4.ClH/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10;/h2-6,11-16,19H,7-9H2,1H3;1H/t11-,12-,13-,14+,15-,16+;/m1./s1

InChI key

KXPXJGYSEPEXMF-MOUKNHLCSA-N

Gene Information

human ... CHRM1(1128)

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Biochem/physiol Actions

Competitive nonselective muscarinic acetylcholine antagonist.
Competitive nonselective muscarinic acetylcholine antagonist. Scopolamine-induced amnesia in laboratory animals is a commonly-used model of memory deficit.

Disclaimer

The powder is stable at least four years stored at room temperature.

pictograms

Skull and crossbonesCorrosion

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

170.6 °F - closed cup

flash_point_c

77 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Stacey J Sukoff Rizzo et al.
Current protocols in mouse biology, 8(2), e45-e45 (2018-06-21)
The relationship between chronological age (lifespan) and biological age (healthspan) varies amongst individuals. Understanding the normal trajectory and characteristic traits of aging mice throughout their lifespan is important for selecting the most reliable and reproducible measures to test hypotheses. The
X Bian et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 21(9), 969-977 (2009-04-21)
Neuromuscular transmission is crucial for normal gut motility but little is known about its postnatal maturation. This study investigated excitatory/inhibitory neuromuscular transmission in vitro using ileal nerve-muscle preparations made from neonatal (< or =48 h postnatal) and adult ( approximately
Sunjoo Joo et al.
Nature communications, 13(1), 1133-1133 (2022-03-05)
Most sexual organisms inherit organelles from one parent, commonly by excluding organelles from the smaller gametes. However, post-mating elimination of organelles derived from one gamete ensures uniparental inheritance, where the underlying mechanisms to distinguish organelles by their origin remain obscure.
Yi-Kuei Wong et al.
Pharmacology, 93(5-6), 278-285 (2014-08-30)
Methamphetamine abuse may produce cognitive impairment. Baicalein, a bioactive flavonoid, has antioxidative, anti-inflammatory and neuroprotective effects. This study examined the effects of baicalein pretreatment on memory performance in the passive avoidance test after either one dose or an acute binge
Fang-Fang Chen et al.
Oncoimmunology, 9(1), 1831153-1831153 (2020-10-29)
Therapeutic monoclonal antibodies against the PD-L1/PD-1 (programmed death ligand-1/programmed cell death protein-1) axis have achieved great successes in cancer treatments, but the development of small-molecule immunomodulators of the pathway has lagged far behind. We established a cellular coculture assay with

Global Trade Item Number

SKUGTIN
S1013-5G04061836844691
S1013-1G04061836831356

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