S1014
Streptonigrin
from Streptomyces flocculus, ≥98% (HPLC), powder, apoptosis inducer
Synonym(s):
Bruneomycin, Nigrin
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About This Item
Empirical Formula (Hill Notation):
C25H22N4O8
CAS Number:
Molecular Weight:
506.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
223-501-8
MDL number:
Beilstein/REAXYS Number:
599390
Assay:
≥98%
Product Name
Streptonigrin from Streptomyces flocculus, ≥98%
Quality Segment
assay
≥98%
antibiotic activity spectrum
viruses
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
COc1ccc(c(O)c1OC)-c2c(C)c(nc(c2N)-c3ccc4C(=O)C(OC)=C(N)C(=O)c4n3)C(O)=O
InChI
1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)
InChI key
PVYJZLYGTZKPJE-UHFFFAOYSA-N
Biochem/physiol Actions
Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| S1014-5MG | 04061836846343 |
| S1014-1MG | 04061836844714 |