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S1437

Sex Hormone-Binding Globulin from human serum

Name: Sex Hormone-Binding Globulin from human serum
Brand: SIGMA

≥95% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

SHBG, Testosterone-estradiol binding globulin

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD00163748

Form:

buffered aqueous glycerol solution

Assay:

≥95% (SDS-PAGE)

Biological source:

human serum

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Properties

biological source

human serum

Quality Level

200

assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P04278

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SHBG(6462)

Description

General description

Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.

Application

Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.

Biochem/physiol Actions

Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.

Physical form

Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain

Konkle ATM and McCarthy MM

Endocrinology, 152(1), 223-235 (2011)

Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China
A STROBE-compliant article

Yuan-rong Cui

Medicine (2017)

Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.

Fortunati N

Molecular and Cellular Endocrinology (2010)

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Global Trade Item Number

SKU	GTIN
S1437-10UG	04061838072047