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S1442

Sordarin sodium salt

Name: Sordarin sodium salt
Brand: SIGMA

From Sordaria araneosa, ≥98% (HPLC), eukaryotic protein synthesis inhibitor, solid

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₃₉NaO₈

CAS Number:

463356-00-5

Molecular Weight:

514.58

UNSPSC Code:

51111800

PubChem Substance ID:

24899480

NACRES:

NA.77

MDL number:

MFCD08277029

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Product Name

Sordarin sodium salt, from Sordaria araneosa, ≥98% (HPLC), solid

biological source

Sordaria araneosa

Quality Segment

200

assay

≥98% (HPLC)

form

solid

solubility

H₂O: soluble ≤10 mg/mL

antibiotic activity spectrum

fungi

mode of action

protein synthesis | interferes

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Na+].[H]C(=O)[C@]12C[C@]3([H])C=C(C(C)C)[C@@]1(C([O-])=O)[C@]3(CO[C@@H]4O[C@H](C)[C@@H](OC)[C@@H](O)[C@@H]4O)C[C@]5([H])[C@H](C)CC[C@@]25[H]

InChI

1S/C27H40O8.Na/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23;/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32);/q;+1/p-1/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+;/m1./s1

InChI key

ILUKWKGTAAZHDW-IGICPMPSSA-M

Description

Application

Soradrin sodium salt has been used as an antifungal compound to treat mycelia for immunofluorescence microscopy studies. It may be used in in vitro diphtheria toxin sensitivity assays.

Biochem/physiol Actions

Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c