Anti-Synapsin II antibody produced in rabbit

Synapsin II (SYN-2) is a neuronal phosphoprotein present in synaptic vesicles. The SYN-2 gene is mapped to human chromosome 3p25.2. Structurally, synapsin types have a conserved N -terminal region and vary in their C-terminal region.

synthetic peptide corresponding to amino acids 438-453 located near the C-terminus of rat synapsin II, conjugated to KLH. This sequence is identical in rat synapsin IIa and IIb isoforms and mouse synapsin II, and is highly conserved in human synapsin IIa and IIb (one amino acid substitution).

Anti-Synapsin II antibody produced in rabbit may be used in immunoblotting.

Anti-Synapsin II specifically recognizes human, rat, and mouse synapsin IIa and Iib.

Synapsins regulate synaptic vesicle clustering, neurotransmitter release, and the formation of synaptic terminals. Synapsin II is involved in the formation of synaptic terminals during neuronal development. Similar to synapsin I, synapsin II can link synaptic vesicles to the actin cytoskeleton, thus regulating the availability of synaptic vesicles for exocytosis. Synapsin II association with synaptic vesicles is controlled by phosphorylation. Synapsin II is proposed as a candidate associated with increased vulnerability to schizophrenia. It is also implicated in synaptogenesis and neurotransmitter release impairment in multiple neuropsychiatric diseases.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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