S3007
Sodium salicylate
ReagentPlus®, ≥99.5% (titration)
Synonym(s):
2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate
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About This Item
Linear Formula:
HOC6H4COONa
CAS Number:
Molecular Weight:
160.10
Beilstein:
3732792
EC Number:
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.25
Assay:
≥99.5% (titration)
Form:
crystalline
Solubility:
water: 575.7 g/L at 25 °C (77 °F)
Quality Level
product line
ReagentPlus®
Assay
≥99.5% (titration)
form
crystalline
color
white
useful pH range
6.85 (26.3 °C)
mp
>300 °C (lit.)
solubility
water: 575.7 g/L at 25 °C (77 °F)
SMILES string
[Na+].Oc1ccccc1C([O-])=O
InChI
1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChI key
ABBQHOQBGMUPJH-UHFFFAOYSA-M
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General description
Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro. Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.
Application
Sodium salicylate has been used:
- to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential.
- to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats.
- to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique.
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
208.9 °F - Pensky-Martens closed cup
Flash Point(C)
98.3 °C - Pensky-Martens closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Effect of Long-Term Sodium Salicylate Administration on Learning, Memory, and Neurogenesis in the Rat Hippocampus
Niu H, et al.
BioMed Research International, 2018, 63-76 (2018)
Local application of sodium salicylate enhances auditory responses in the rat?s dorsal cortex of the inferior colliculus
Patel, Chirag R and Zhang, Huiming
Frontiers in Neurology, 5, 235-235 (2014)
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