S3134
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
lyophilized powder, ≥2,000 units/mg solid
Synonym(s):
Streptokinase from Streptococcus hemolyticus
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About This Item
CAS Number:
eCl@ss:
32160410
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-647-1
MDL number:
Product Name
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C), lyophilized powder, ≥2,000 units/mg solid
SMILES string
N1C(CC(C1)C2CCCCC2)C(=O)O
InChI
1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
InChI key
XRZWVSXEDRYQGC-UHFFFAOYSA-N
form
lyophilized powder
specific activity
≥2,000 units/mg solid
shipped in
wet ice
storage temp.
−20°C
Quality Level
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Physical form
Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.
Application
Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.
Biochem/physiol Actions
Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.
General description
Research area: Cell signaling
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.
Other Notes
One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Effects of plasminogen and streptokinase on the vital functions of nervous tissue cells in culture
Nikandrov, V., et al.
Biomeditsinskaia Khimiia, 54, 192-200 (2012)
Ansar S Zhalyalov et al.
PloS one, 12(7), e0180668-e0180668 (2017-07-08)
Fibrinolysis is a cascade of proteolytic reactions occurring in blood and soft tissues, which functions to disintegrate fibrin clots when they are no more needed. In order to elucidate its regulation in space and time, fibrinolysis was investigated using an
Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East
Al-Zakwani, I., et al.
Journal of the American Medical Association, 34(3), 445-451 (2012)
André Busch et al.
International journal of molecular sciences, 21(17) (2020-09-06)
During total joint replacement, high concentrations of mesenchymal stromal cells (MSCs) are released at the implantation site. They can be found in cell-tissue composites (CTC) that are regularly removed by surgical suction. A surgical vacuum suction handle was filled with
Role of streptokinase in the treatment of acute loculated parapneumonic pleural effusions and empyema
Bouros D, et al.
Thorax, 49(9), 852-855 (1994)
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