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S3147

5-Sulfosalicylic acid dihydrate

Name: 5-Sulfosalicylic acid dihydrate
Brand: SIGMA

suitable for electrophoresis, ≥99%

Synonym(s):

2-Hydroxy-5-sulfobenzoic acid

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About This Item

Linear Formula:

HO₃SC₆H₃-2-(OH)CO₂H·2H₂O

CAS Number:

5965-83-3

Molecular Weight:

254.21

UNSPSC Code:

41105319

NACRES:

NB.22

PubChem Substance ID:

24899547

EC Number:

202-555-6

Beilstein/REAXYS Number:

650741

MDL number:

MFCD00149540

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Quality Level

200

assay

≥99%

form

powder or crystals

technique(s)

electrophoresis: suitable

impurities

≤0.02% Insoluble matter, ≤0.05% Salicylic Acid

mp

105-110 °C (lit.)

solubility

water: soluble 100 mg/mL, clear, colorless

anion traces

chloride (Cl^-): ≤0.001%, sulfate (SO₄^2-): ≤0.035%

cation traces

Fe: ≤0.001%, heavy metals (as Pb): ≤0.002%

SMILES string

[H]O[H].[H]O[H].OC(=O)c1cc(ccc1O)S(O)(=O)=O

InChI

1S/C7H6O6S.2H2O/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10;;/h1-3,8H,(H,9,10)(H,11,12,13);2*1H2

InChI key

BHDKTFQBRFWJKR-UHFFFAOYSA-N

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General description

5-Sulfosalicylic acid is a strong acid capable of protonating water. It forms a new theophylline complex, which was investigated by X-ray photoelectron spectroscopy (XPS). It forms 1:1 proton-transfer compounds with the ortho-substituted monocyclic heteroaromatic Lewis bases. Their crystal structures have been studied.

Application

5-Sulfosalicylic acid dihydrate may be employed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma by HPLC. It may be used in the preparation of poly[[tris(di-2-pyridylamine)tris([μ]-5-sulfonatosalicylato)tricopper(II)] trihydrate].

5-Sulfosalicylic acid (3.5%) in 12% trichloroacetic acid is commonly used as a fixing solution for proteins in agarose and polyacrylamide gels.

Analysis Note

Tested for use in fixing solutions for PAGE, SDS-PAGE and IEF.

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Rapid determination of PEGylated liposomal doxorubicin and its major metabolite in human plasma by ultraviolet-visible high-performance liquid chromatography.

David L Chin et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 779(2), 259-269 (2002-10-04)

A high-performance liquid chromatographic method was developed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma. This method utilizes Triton X-100 to disperse the liposome, followed by a protein precipitation step

5-Hydroxytryptophan Suppresses the Abdominal Fat Deposit and Is Beneficial to the Intestinal Immune Function in Broilers.

Hui Wang et al.

Frontiers in physiology, 11, 655-655 (2020-07-01)

Serotonin (5-HT), a monoaminergic neurotransmitter, involves in the regulation of many physiological functions. In the present study, the effects of 5-hydroxytryptophan (5-HTP), the precursor of 5-HT, on lipid metabolism and intestinal immune function in broiler chickens were investigated in chickens.

Identification of protonation state by XPS, solid-state NMR, and DFT: characterization of the nature of a new theophylline complex by experimental and computational methods.

Joanna S Stevens et al.

The journal of physical chemistry. B, 114(44), 13961-13969 (2010-10-22)

Recent studies suggested that X-ray photoelectron spectroscopy (XPS) sensitively determines the protonation state of nitrogen functional groups in the solid state, providing a means for distinguishing between co-crystals and salts of organic compounds. Here we describe how a new theophylline

Carbon monoxide increases utero-placental angiogenesis without impacting pregnancy specific adaptations in mice.

Megan A Dickson et al.

Reproductive biology and endocrinology : RB&E, 18(1), 49-49 (2020-05-16)

Cigarette smokers have a reduced risk of developing preeclampsia, possibly attributed to an increase in carbon monoxide (CO) levels. Carbon monoxide is a gasotransmitter that has been implicated in maintaining vascular tone, increasing angiogenesis, and reducing inflammation and apoptosis at

Poly [[tris (di-2-pyridylamine) tris (μ-5-sulfonatosalicylato) tricopper (II)] trihydrate].

Fan SR and Zhu LG.

Acta Crystallographica Section E, Structure Reports Online, 61(1), m174-m176 (2004)

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Global Trade Item Number

SKU	GTIN
S3147-500G	04061836921798
S3147-100G	04061836921750

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