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Merck
CN

S3322

Supercinnamaldehyde

≥98% (HPLC)

Synonym(s):

1,3-Dihydro-1-methyl-3-(2-oxopropylidene)-2H-Indol-2-one

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About This Item

Empirical Formula (Hill Notation):
C12H11NO2
CAS Number:
70351-51-8
Molecular Weight:
201.22
NACRES:
NA.77
PubChem Substance ID:
329824530
UNSPSC Code:
12352200
MDL number:
MFCD08530327

Key Documents

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InChI key

CZKBLHCEDVWPRN-JXMROGBWSA-N

SMILES string

CN1C(=O)C(=C\C(C)=O)\c2ccccc12

InChI

1S/C12H11NO2/c1-8(14)7-10-9-5-3-4-6-11(9)13(2)12(10)15/h3-7H,1-2H3/b10-7+

assay

≥98% (HPLC)

form

powder

color

faintly red to very dark red

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

200

Application

Supercinnamaldehyde may be used in transient receptor potential ankyrin 1 (TRPA 1)-mediated cell signaling studies.

Biochem/physiol Actions

Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator. EC50 = 0.8 μM.
Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator; EC50 = 0.8 μM; derivative of cinnamaldehyde; covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.

Disclaimer

Air-sensitive

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000281413
0000281413
0000132183
0000132184
0000105197

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