S3322
Supercinnamaldehyde
≥98% (HPLC)
Synonym(s):
1,3-Dihydro-1-methyl-3-(2-oxopropylidene)-2H-Indol-2-one
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About This Item
Empirical Formula (Hill Notation):
C12H11NO2
CAS Number:
Molecular Weight:
201.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
faintly red to very dark red
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN1C(=O)C(=C\C(C)=O)\c2ccccc12
InChI
1S/C12H11NO2/c1-8(14)7-10-9-5-3-4-6-11(9)13(2)12(10)15/h3-7H,1-2H3/b10-7+
InChI key
CZKBLHCEDVWPRN-JXMROGBWSA-N
Application
Supercinnamaldehyde may be used in transient receptor potential ankyrin 1 (TRPA 1)-mediated cell signaling studies.
Biochem/physiol Actions
Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator. EC50 = 0.8 μM.
Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator; EC50 = 0.8 μM; derivative of cinnamaldehyde; covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.
Disclaimer
Air-sensitive
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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