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Merck
CN

S3386

Sorbitan sesquioleate

nonionic surfactant

Synonym(s):

Arlacel® 83, Span® 83

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About This Item

CAS Number:
8007-43-0
NACRES:
NA.25
PubChem Substance ID:
329824531
UNSPSC Code:
12352211
EC Number:
232-360-1
MDL number:
MFCD00151568

Key Documents

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Product Name

Sorbitan sesquioleate, nonionic surfactant

InChI key

SPFRYHCSFBFNTR-RKGWDQTMSA-N

InChI

1S/3C18H34O2.2C6H12O5/c3*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;2*7-1-3(8)6-5(10)4(9)2-11-6/h3*9-10H,2-8,11-17H2,1H3,(H,19,20);2*3-10H,1-2H2/b3*10-9-;;/t;;;2*3-,4+,5-,6-/m...11/s1

SMILES string

OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C2OC[C@H](O)[C@H]2O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O

biological source

corn

vapor pressure

0.81 psi ( 20 °C)

form

liquid

refractive index

n20/D 1.478 (lit.)

density

0.989 g/mL at 25 °C (lit.)

functional group

ester

lipid type

oils

shipped in

ambient

storage temp.

room temp

Quality Level

200

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Biochem/physiol Actions

Sorbitan sesquioleate is useful as a stabilizing agent in polymerization process to produce spherical acrylamide beads. It has been used in many topical agents. SSO have recently been implicated in allergic dermatitis.

General description

Sorbitan sesquioleate (SSO) is a sorbitol derivative emulsifier. It is a common emulsifier component in topical corticosteroids, topical antibiotics, topical antifungals, moisturizing creams and lotions and topical retinoids.

Other Notes

Fatty acid composition: Oleic acid (C18:1) approx. 70%; balance primarily palmitic acid (C16:0), stearic acid (C18:0) and linoleic acid (C18:2).

Legal Information

Arlacel is a registered trademark of Croda International PLC
Span is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW5364
MKCQ4316
MKCM4323
MKCH0477
MKCD1853

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The Validity of Patch Testing
Lachapelle JM, et al.
Patch Testing Tips, 49(4), 37-61 (2014)
S Fukanoki et al.
Avian diseases, 44(4), 869-873 (2001-02-24)
The relationship between the antigen release from formulations in vitro and the antibody response after administration of water-in-oil-in-water (W/O/W) emulsion vaccines containing Haemophilus paragallinarum (Hpg) was studied in chickens. Increases of sorbitan sesquioleate volume in the formulation led to slower
Contact urticaria syndrome from sorbitan sesquioleate in a corticosteroid ointment.
M Hardy et al.
Contact dermatitis, 32(6), 360-361 (1995-06-01)
M Iwata et al.
Journal of microencapsulation, 16(1), 49-58 (1999-02-11)
PLGA multiphase microspheres were prepared by the multiple emulsion solvent evaporation method using acetonitrile as the polymer solvent and mineral oil as the evaporation medium. The preparation process was further developed in the present study to reduce the particle size
E Larmi et al.
Contact dermatitis, 19(5), 368-371 (1988-11-01)
In order to study the effects of an emulsifier on non-immunologic immediate contact reactions, 500, 250, 125, 62, and 31 mM benzoic acid (BA) was tested in 12 medical students on a skin area of the upper back treated with
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