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Merck
CN

S3884

Sauvagine

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C202H346N56O63S
CAS Number:
Molecular Weight:
4599.31
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
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assay

≥97% (HPLC)

storage temp.

−20°C

InChI key

ILCVKEBXPLEGOY-ZLFMSJRASA-N

General description

Sauvagine is a polypeptide derived from the frog skin. It belongs to the CRH (corticotropin releasing factor) family. Sauvagine is made of 40 amino acids. It may also be found in the brain of mammals.

Biochem/physiol Actions

Sauvagine helps to liberate ACTH (adrenocorticotropic hormone) from the pituitary cells of rat. It has several important functions in the cardiovascular, endocrine and renal systems.
A peptide related to CRF and urotensin 1 that was first isolated from the skin of the frog Phyllomedusa sauvagei. Potent releaser of ACTH and β-endorphin from the anterior pituitary.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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James L Goodson et al.
Hormones and behavior, 50(2), 223-236 (2006-04-29)
Neuroendocrine factors that produce species differences in aggregation behavior ("sociality") are largely unknown, although relevant studies should yield important insights into mechanisms of affiliation and social evolution. We here focused on five species in the avian family Estrildidae that differ
Satoko Ise et al.
Brain research, 1234, 59-65 (2008-08-16)
An infant animal isolated from its mother emits vocalizations spanning from the audible to the ultrasonic. These vocalizations are believed to represent distress signals from the pup. However, the neurobiological basis for vocalizations elicited by isolation has not been well
David A Lovejoy et al.
General and comparative endocrinology, 146(1), 1-8 (2006-02-14)
The corticotropin-releasing factor (CRF) family of peptides consists of four distinct paralogs found on separate chromosomes in vertebrates. Among invertebrates, the family has been relatively well characterized in the insects where at least 2 or 3 paralogs, a CRF-binding protein
Lisa Frommelt et al.
Peptides, 39, 111-118 (2012-12-04)
Studies have shown a reduction of food intake following peripheral and brain injection of CCK. However, it remains to be established whether endogenous central CCK is involved in the regulation of food intake. We investigated the role of central CCK
Takeshi Nakamura et al.
American journal of physiology. Heart and circulatory physiology, 296(2), H325-H332 (2008-12-09)
Urocortin 3 (Ucn3) is a new member of the corticotropin-releasing factor (CRF) peptide family and is considered to be a specific and endogenous ligand for CRF type 2 receptors (CRF2Rs). The presence of CRF(2)Rs has been reported in the nucleus

Global Trade Item Number

SKUGTIN
S3884-250UG04061832677774
S3884-.5MG04061832677750

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